Synthesis and structure of 2-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalene)]-5-benzimidazole ethylcarboxylate monohydrate |
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Authors: | Zeynep Ates-Alagoz Sibel Suzen Erdem Buyukbingol Mino R Caira |
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Institution: | (1) Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Tandogan, Ankara University, 06100 Ankara, Turkey;(2) Department of Chemistry, University of Cape Town, Rondebosch, 7701, South Africa |
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Abstract: | As part of a program investigating the conformations of potential anticarcinogens and antioxidants, the structure of the title compound C24H28N2O2·H2O is reported. The monohydrate crystallizes in the monoclinic space group P2/c with unit cell parameters a = 16.184(1),b = 7.937(1), c = 16.968(1), = 92.788(7)°, and Z = 4. The benzimidazole and tetrahydrotetramethylnaphthalene ring systems are inclined to one another by approximately 26°. The water molecule plays an important role in the crystal structure by hydrogen bonding to different functional groups of three organic moieties. Additional crystal stabilization is dueto – stacking of benzimidazole rings. |
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Keywords: | retinoic acid analog benzimidazole anticarcinogenic/antioxidant |
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