Condensed Isoquinolines. 12. Synthesis of Novel Heterocyclic Systems Containing a Partially Hydrogenated Spiro[isoquinoline-4,4'-(2H)-pyran] Fragment |
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Authors: | V. M. Kisel E. O. Kostyrko M. O. Platonov V. A. Kovtunenko |
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Affiliation: | (1) Taras Shevchenko National University, Kiev, 01033, Ukraine |
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Abstract: | By condensation of 4-(2-bromomethyl)-3,4,5,6-tetrahydro-2H-pyran-4-carbonitrile with anthranilic acid, its derivatives substituted in the benzene ring (esters, nitrile), and with esters of 2-aminothiophene-3-carboxylic acids and 3-amino-5-bromobenzofuran-2-carboxylic acid there have been synthesized novel derivatives which include spiro-linked tetrahydropyran and 5,10-dihydro-3H-pyrimido[1,2-b]isoquinoline fragments. The pyrimidine ring of the latter was annelated by a substituted benzene, thiophene, or 5-bromobenzofuran ring. |
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Keywords: | benzofuropyrimidine isoquinoline condensed isoquinolines spirocyclic compounds tetrahydropyran hienopyrimidine quinazoline |
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