Synthesis of (-)-amphidinolide K fragment C9-C22 |
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Authors: | Andreou Thanos Costa Anna M Esteban Laia Gonzàlez Lluïsa Mas Gemma Vilarrasa Jaume |
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Affiliation: | Departament de Química Orgànica, Facultat de Química, Av. Diagonal 647, Universitat de Barcelona, 08028 Barcelona, Catalonia, Spain. |
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Abstract: | [reaction: see text] The key fragment (2a or 2b) in a total synthesis of the cytotoxic macrolide (-)-amphidinolide K (1) has been achieved from synthons C9-C14 (3) and C15-C22 (4), which have both been prepared from glutamic acid in good overall yields. |
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