Transport properties of Chitosan-Amikacin films |
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| Authors: | E I Kulish A S Shurshina S V Kolesov |
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| Institution: | 1. Bashkir State University, Ufa, Russia
2. Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, Ufa, Russia
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| Abstract: | The transport properties of films based on chitosan and a drug have been studied, and sorption and diffusion characteristics of the films have been examined. The calculated diffusion coefficients and the abnormal kinetic curves of amikacin release have been discussed. An analysis of the obtained data showed that the process of drug transport from chitosan films deviated from the classical Fick’s laws due to structural changes in the polymer matrix induced by its chemical modification because of interaction with the drug. |
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