Regularities of formation of emboli of liquid polymer solutions in aqueous medium |
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| Authors: | O. A. Legon’kova V. N. Dan S. V. Sapelkin S. A. Kedik E. S. Zhavoronok A. V. Panov L. Yu. Asanova P. L. Ogarkova M. S. Shilov |
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| Affiliation: | 1.Vishnevsky Institute of Surgery,Ministry of Healthcare of the Russian Federation,Moscow,Russia;2.Moscow State University of Fine Chemical Technology,Moscow,Russia |
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| Abstract: | Work on creating the basis for embolic compositions for the treatment of a wide range of pathologies of various organs was conducted. This basis is a solution of a biocompatible water-insoluble polymer in a biocompatible water-soluble solvent. Formation of the embolus in such an aqueous medium takes place in the transition of the solvent into the aqueous phase and the formation of a solid polymer clot occluding a blood vessel. Criteria for selection of the polymer and the solvent for the basis were formulated, and a number of polymers and solvents that meet these criteria were selected for further research. Research on the solubility of the selected polymers in solvents was carried out, and the rheoviscometric characteristics of polymer solutions, as well as parameters of solid emboli formation of polymer solutions in aqueous media, were found. The solution of cellulose acetate plasticized with OPADRY CA 500F190000 polyethylene glycol in dimethylsulfoxide with concentration of no less than 60 g/L was recognized as optimal for further studies. |
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