Conformational analysis of polymethylated derivatives of piperidine by the method of molecular mechanics

The conformational (steric) energies of different conformers and thus the type of dominant conformation were determined by the method of molecular mechanics for polysubstituted derivatives of piperidine. The chair conformation dominates for polymethylated 4-piperidines. The half-chair conformation is preferred for 1-methyl-3-methylene-4-piperidone, and the sofa conformation is preferred for analogous polymethylated enones.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 1, pp. 91–97, January, 1991.