| 鼻咽癌细胞分泌物的拉曼光谱研究 |
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| 引用本文： | 高健赫,蔡红星,张喜和.鼻咽癌细胞分泌物的拉曼光谱研究[J].光散射学报,2012,24(2):186-192. |
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| 作者姓名： | 高健赫 蔡红星 张喜和 |
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| 作者单位： | 长春理工大学国际纳米光子学与生物光子学联合研究中心,长春,130022 |
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| 摘 要： | Plasminogen Activator Inhibitor 1(纤溶酶原激活物抑制物1, 简称PAI-1)在鼻咽癌(Nasopharyngeal Carcinoma, 简称NPC)分泌物中大量存在。本文绘制了Plasminogen Activator Inhibitor 1的分子结构, 根据局部能量最低原理对其做了结构优化, 给出了空间结构参数, 然后利用DFT B3LYP/3-21G基组计算了其拉曼光谱, 并对102 cm-1至4559 cm-1区间的谱线进行指认。理论计算Plasminogen Activator Inhibitor 1的拉曼光谱将有助于鼻咽癌的临床检测技术的提高。
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| 关 键 词： | 拉曼光谱计算 纤溶酶原激活物抑制物1 谱指认 |
| 收稿时间： | 2011/6/30 |
Using Raman Spectroscopy to Study the Secretion of Nasopharyngeal Carcinoma |
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| GAO Jian-he
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CAI Hong-xing
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ZHANG Xi-he.Using Raman Spectroscopy to Study the Secretion of Nasopharyngeal Carcinoma[J].Chinese Journal of Light Scattering,2012,24(2):186-192. |
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| Authors: | GAO Jian-he CAI Hong-xing ZHANG Xi-he |
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| Institution: | (International Joint Research Center for Nanophotonis and Biophotnics of Changchun University of Science and Technology,Changchun 130022,China) |
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| Abstract: | Plasminogen Activator Inhibitor 1(PAI-1) is the primary protein detected in secretory of Nasopharyngeal Carcinoma(NPC).The structure of Plasminogen Activator Inhibitor 1 has been draught and optimized by principle of the lowest energy.By base DFT B3LYP/3-21G,analyzing the relationship between its spectrum and molecular activities involved in the assignments between 102 cm-1 to 4559 cm-1.All the calculation above could promote the development of the clinical test of Nasopharyngeal Carcinoma by utilizing Raman spectroscopy technology. |
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| Keywords: | Raman spectroscopy calculation plasminogen activator inhibitor 1 spectroscopy assignments |
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