| 硝唑尼特的合成与表征 |
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| 引用本文： | 徐庐峰,冯晓亮,吴微,许丹萍.硝唑尼特的合成与表征[J].光谱实验室,2012,29(2):843-846. |
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| 作者姓名： | 徐庐峰 冯晓亮 吴微 许丹萍 |
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| 作者单位： | 衢州学院化学与材料工程学院,浙江省衢州市九华路78号,324000 |
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| 基金项目： | 浙江省科技厅公益性项目(No.2011C31036);浙江省大学生科技创新项目(No.2010R427011);浙江省衢州市科技局项目(No.20101055) |
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| 摘 要： | 邻乙酰水杨酸经氯化亚砜酰氯化制得邻乙酰水杨酰氯,以N,N′-二乙基甲酰胺为溶剂,吡啶为缚酸剂,与2-氨基-5-硝基噻唑缩合反应制得硝唑尼特,收率为78.9%(以2-氨基-5-硝基噻唑计),含量为98.8%(HPLC)。化合物结构经1H NMR、IR确证。
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| 关 键 词： | 邻乙酰水杨酸 硝唑尼特 2-氨基-5-硝基噻唑 |
Synthesis and Characterization of Nitazoxanide |
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| XU Lu-Feng
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FENG Xiao-Liang
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WU Wei
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XU Dan-Ping.Synthesis and Characterization of Nitazoxanide[J].Chinese Journal of Spectroscopy Laboratory,2012,29(2):843-846. |
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| Authors: | XU Lu-Feng FENG Xiao-Liang WU Wei XU Dan-Ping |
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| Institution: | XU Lu-Feng FENG Xiao-Liang WU Wei XU Dan-Ping(School of Chemical and Materical Engineering,Quzhou University,Quzhou,Zhejiang 324000,P.R.China) |
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| Abstract: | o-Acetylsalicylryl chloride was synthesized by acetylsalicylic acid and sulfurous oxychloride.Nitazoxanide was synthesized by 2-amino-5-nitro-thiazole and o-acetylsalicylryl chloride,with N,N′-diethylformamide as solvent and pyridine as tied acid agents,The yield was 78.9% with 2-amino-5-nitro-thiazole as calculation,and the purity of nitazoxanide was 98.8% by HPLC.The structure of the product was identified by IR and 1H NMR. |
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| Keywords: | Acetylsalicylic Acid Nitazoxanide 2-Amino-5-Nitro-Thiazole |
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