LC Method for the Determination of Multiple Components in a Compound Cold Formulation |
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Authors: | Meiling Qi Peng Wang Jie Chen |
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Affiliation: | (1) Department of Chemistry, School of Chemical Engineering and Materials Science, Beijing Institute of Technology, Beijing, 100081, China;(2) Shenyang Pharmtech Institute of Pharmaceuticals, 33 Wencui Road, Shenyang, 110016, China |
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Abstract: | An isocratic liquid chromatographic method for determination of acetaminophen (AMP), caffeine (CAF), chlorphenamine maleate (CPM) and guaiacol glyceryl ether (GGE) in a compound cold formulation is described. Separation and quantitation were achieved on a Diamonsil C18 column using a binary mixture of methanol and 1.5% aqueous acetic acid (55: 45, v/v, pH 3.6) as mobile phase delivered at 0.4 mL min–1. Single wavelength detection was at 220 nm for all four drugs and the run time was < 10 min. The linearity, accuracy and precision of the method were found to be acceptable over the concentration ranges: 16.0–127.8 g mL–1 for AMP, 6.0–48.2 g mL–1 for CAF, 5.0–40.0 g mL–1 for CPM and 10.1–80.6 g mL–1 for GGE. |
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Keywords: | Column liquid chromatography Components of a cold formulation Acetaminophen Caffeine Chlorphenamine maleate and Guaiacol glyceryl ether |
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