| A new strategy for the stereoselective synthesis of 2,3-dideoxy-3-fluoro-D-ribofuranose derivatives |
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| 引用本文： | GUO,Zhong-Wu HUANG,Bao-Guo XIAO,Wen-Juan HUI,Yong-ZhengShanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai ?0032,ChinaLANG,Stanley A.,Jr.Medical Research Division,American Cyanamid Company,Pearl River,NY 10965,USA. A new strategy for the stereoselective synthesis of 2,3-dideoxy-3-fluoro-D-ribofuranose derivatives[J]. 中国化学, 1995, 13(4): 363-367. DOI: 10.1002/cjoc.19950130412 |
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| 作者姓名： | GUO Zhong-Wu HUANG Bao-Guo XIAO Wen-Juan HUI Yong-ZhengShanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai ?0032 ChinaLANG Stanley A. Jr.Medical Research Division American Cyanamid Company Pearl River NY 10965 USA |
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| 作者单位： | GUO，Zhong-Wu HUANG，Bao-Guo XIAO，Wen-Juan HUI，Yong-ZhengShanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai ?0032，ChinaLANG，Stanley A.，Jr.Medical Research Division，American Cyanamid Company，Pearl River，NY 10965，USA |
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| 摘 要： | The important intermediate for syntheses of various anti-HIV nucleoside analogues, methyl 2,3-dideoxy-3-fluoro-6-O-(p-methylbenzoyl)-a-D-ribofuranoside, was synthesized starting from 2-deoxy-D-ribose in 5 steps with an overall yield of 24%. This strategy can be also used for synthesizing other analogues with various substitutions at 3-C position.
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A new strategy for the stereoselective synthesis of 2,3-dideoxy-3-fluoro-D-ribofuranose derivatives |
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| GUO,Zhong-Wu HUANG,Bao-Guo XIAO,Wen-Juan HUI,Yong-Zheng. A new strategy for the stereoselective synthesis of 2,3-dideoxy-3-fluoro-D-ribofuranose derivatives[J]. Chinese Journal of Chemistry, 1995, 13(4): 363-367. DOI: 10.1002/cjoc.19950130412 |
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| Authors: | GUO Zhong-Wu HUANG Bao-Guo XIAO Wen-Juan HUI Yong-Zheng |
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| Affiliation: | GUO,Zhong-Wu HUANG,Bao-Guo XIAO,Wen-Juan HUI,Yong-ZhengShanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai ?0032,ChinaLANG,Stanley A.,Jr.Medical Research Division,American Cyanamid Company,Pearl River,NY 10965,USA |
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| Abstract: | The important intermediate for syntheses of various anti-HIV nucleoside analogues, methyl 2,3-dideoxy-3-fluoro-6-O-(p-methylbenzoyl)-a-D-ribofuranoside, was synthesized starting from 2-deoxy-D-ribose in 5 steps with an overall yield of 24%. This strategy can be also used for synthesizing other analogues with various substitutions at 3-C position. |
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| Keywords: | New method stereoselective synthesis 2 3-dideoxy-3-substituted-D-ribofuranoside |
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