Inclusion complexes of the natural product gossypol. The formation of different gossypol polymorphs on decomposition of channel type inclusion complexes

The existence of seven gossypol polymorphs has been established. Two of them are obtained by direct crystallization from solution. The remaining five polymorphs are the products of desolvation of channel type complexes (tubulates). Each isostructural group of the complexes on decomposition gives one polymorph. Gossypol thus possesses specific peculiarities in terms of the decomposition of its tubulates, and also the absence of thermotropic polymorphic transitions.