Microwave assisted,sequential two-step,one-pot synthesis of novel imidazo[1,2-a]pyrimidine containing tri/tetrasubstituted imidazole derivatives |
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Authors: | Tuba GÜNG
R |
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Institution: | 1. Department of Chemistry, Faculty of Sciences and Arts, Natural Products and Drug Research Laboratory,Çanakkale Onsekiz Mart University, Çanakkale, Turkey |
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Abstract: | A series of novel imidazo1,2- a ]pyrimidine containing tri/tetrasubstituted imidazole derivatives (1-10) has been synthesized via sequential two-step, one-pot, multicomponent reaction using imidazo1,2- a ]pyrimidine-2-carbaldehyde, benzil, primary amines, and ammonium acetate catalyzed by p -toluenesulfonic acid under microwave-assisted conditions. The results showed that target compounds can be obtained from a wide range of primary amines bearing different functional groups with moderate to good yields (46%-80%) under optimum reaction conditions. This method provides a green protocol for imidazo1,2- a ]pyrimidine containing tri/tetrasubstituted imidazole derivatives due to ethyl alcohol as a green solvent, microwave irradiation as a greener heating method and one-pot multicomponent reaction as a green technique. The synthesized compounds have been elucidated using various spectroscopic tools such as FT-IR, 1H NMR, 13 C NMR, and MS. |
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Keywords: | Imidazo[1 2-
a
]pyrimidine tri/tetrasubstituted imidazole microwave synthesis sequential one-pot reaction p
-toluenesulfonic acid |
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