Evaluation of the sonosensitizing properties of nano-graphene oxide in comparison with iron oxide and gold nanoparticles |
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| Institution: | 1. Medical Physics Department, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran;2. Biochemistry Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran;1. School of Physical Electronics, Joint Laboratory for Police Equipment Research, University of Electronic Science and Technology of China, Chengdu 610054, PR China;2. School of Physics and Mech-tronic Engineering, Sichuan University of Arts and Science, Dazhou 635000, PR China;1. Department of Physics and Astronomy, University of Manitoba, Winnipeg, Canada R3T 2N2;2. Department of Physics/Theoretical Physics, University of Oulu, Oulu FIN-90014, Finland;1. College of Chemistry, Chemical Engineering and Environmental Engineering, Liaoning Shihua University, Fushun 113001, PR China;2. School of New Energy, Shenyang Institute of Engineering, Shenyang 110136, PR China;3. College of Petroleum Engineering, Liaoning Shihua University, Fushun 113001, PR China;2. School of Electrical Engineering, University of Belgrade, Bulevar kralja Aleksandra 73, 11120 Belgrade, Serbia;3. Institute of Microwaves and Photonics, School of Electronic and Electrical Engineering, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK |
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| Abstract: | In cancer hyperthermia, ultrasound is considered as an appropriate source of energy to achieve desired therapeutic levels of heating. It is assumed that such a heating is targeted to cancer cells by using nanoparticles as sonosensitization agents. Here, we report the sonosensitizing effects of Nano-Graphene Oxide (NGO) and compare them with gold nanoparticles (AuNPs), Iron Oxide nanoparticles (IONPs).Experiments were conducted to explore the effects of nanoparticle type and concentration, as well as ultrasound power, on transient heating up of the solutions exposed by 1 MHz ultrasound. Nanoparticles concentration was selected from 0.25 to 2.5 mg/ml and the solutions were exposed by ultrasound powers from 1 to 8 W. Real time temperature monitoring was done by a thermocouple and obtained data was analyzed.Temperature profiles of various nanoparticle solutions showed the higher heating rates, in comparison to water. Heating rise was strongly depended on nanoparticles concentration and ultrasound power. AuNPs showed a superior efficiency in heat generation enhancement in comparison to IONPs and NGO.Our result supports the idea of sonosensitizing capabilities of AuNPs, IONPs, and NGO. Targeted hyperthermia may be achievable by preferential loading of tumor with nanoparticles and subsequent ultrasound irradiation. |
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| Keywords: | Cancer Nanoparticle Ultrasound Sonosensitizer Heat generation |
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