Synthesis of the first unnatural schisantherins and their effects in multidrug-resistant cancer cells |
| |
Authors: | Rainer Schobert Werner Kern Wolfgang Milius Tamara Ackermann Miroslava Zoldakova |
| |
Institution: | Chemisches Laboratorium der Universität, 95440 Bayreuth, Germany |
| |
Abstract: | Schisandrol A, a dibenzocyclooctadiene lignan, was obtained by a simplified procedure from Schisandra chinensis fruits. Its reaction with carboxylic acids to give new esters (schisantherins) required special conditions such as microwave irradiation. An X-ray single crystal structure analysis of schisandrol A revealed a sterical shielding of the secondary OH group as the likely reason. The cinnamoate inhibited the P-gp drug transporters of multidrug-resistant human Kb-V1 cervix carcinoma cells better than the natural benzoate and comparable to the clinical sensitizer verapamil. |
| |
Keywords: | Schisandra chinensis Esterification Phosphorus ylides Microwave Multidrug resistance |
本文献已被 ScienceDirect 等数据库收录! |