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Organo-catalyzed highly diastereo- and enantio-selective direct aldol reactions in water |
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| Authors: | Jun-Feng Zhao Long He Zhuo Tang Lin-Feng Cun Liu-Zhu Gong |
| Institution: | a Key Laboratory for Asymmetric Synthesis and Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, PR China b Graduate School of Chinese Academy of Sciences, Beijing, PR China c Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry of Science and Technology of China, Hefei 230026, PR China |
| Abstract: | The asymmetric direct aldol reactions of a wide scope of aromatic aldehydes, with unmodified ketones in the presence of 1 mol % of organocatalyst prepared from (2R,3R)-diethyl 2-amino-3-hydroxysuccinate and trans-4-hydroxy-l-proline, were performed in water, affording aldol products in high yields with excellent diastereoselectivities of up to >99:1 and enantioselectivities of up to 98%. |
| Keywords: | Water Organocatalysis Direct aldol Diastereo- and enantio-selective |
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