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Metal-based anticancer agents: targeting androgen-dependent and androgen-independent prostate and COX-positive pancreatic cancer cells by phenanthrenequinone semicarbazone and its metal complexes |
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| Authors: | Zahra Afrasiabi Rosana Almudhafar Di Xiao Ekkehard Sinn Amitava Choudhury Aamir Ahmad Alok Vyas Fazlul Sarkar Subhash Padhye |
| Affiliation: | 1. Department of Life and Physical Sciences, Lincoln University, 252 Founders Hall, 820 Chestnut St., Jefferson City, MO, 65101, USA 2. Department of Chemistry, Western Michigan University, Kalamazoo, MI, USA 3. Department of Chemistry, Missouri University of Science and Technology, Rolla, MO, 65409, USA 4. Karmanos Cancer Research Institute, Wayne State University, Detroit, MI, USA 5. ISTRA, Department of Chemistry, Abeda Inamdar Senior College, University of Pune, Pune, 411001, India |
| Abstract: | A planar, polycyclic and aromatic hydrocarbon ligand, namely 9,10-phenanthrenequinone semicarbazone, and its transition metal complexes have been synthesized and structurally characterized. The in vitro antiproliferative activity of these compounds against five human cancer cell lines revealed that they were effective against androgen receptor-positive/negative prostate cancer cells as well as COX-positive pancreatic BxPC-3 cancer cell line. The driving force behind such antiproliferative activity seems to be the up-regulated COX expression in these cells, which was amenable for targeting through metal complexation. These structural motifs can, therefore, serve as a starting point for developing novel cytotoxic agents against the growing number of prostate and pancreatic cancers. |
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