Radical oxidative cyclization of spiroacetals to bis-spiroacetals: an overview |
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| Authors: | Brimble Margaret A |
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| Institution: | Department of Chemistry, University of Auckland, 23 Symonds St., Auckland, New Zealand. m.brimble@auckland.ac.nz |
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| Abstract: | The use of iodobenzene diacetate and iodine under photolytic conditions provides and efficient method for the oxidative cyclization of spiroacetals bearing an hydroxyalkyl side chain to bis-spiroacetals. An overview is provided of the use of this reaction for the synthesis of several bis-spiroacetal containing natural products such as the polyether antibiotics salinomycin and CP44,161 and the shellfish toxins, the spirolides. |
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