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Immunosuppressive Resveratrol Aneuploids from Hopea chinensis |
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| Authors: | Hui Ming Ge Dr. Wen Hao Yang Yan Shen Dr. Nan Jiang Dr. Zhi Kai Guo Qiong Luo Qiang Xu Prof. Jing Ma Prof. Ren Xiang Tan Prof. |
| Affiliation: | 1. Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, School of Lifesciences, Nanjing University, Nanjing 210093 (China), Fax: (+86)?25‐83302728;2. Institute of Theoretical and Computational Chemistry, Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (China) |
| Abstract: | Two novel resveratrol aneuploids, hopeachinols A ( 1 ) and B ( 2 ), as well as a potent immunosuppressive polyphenol diptoindonesin G ( 3 ) were characterized from the ethanol extract of Hopea chinensis stem barks. The structure of the polyphenols was accommodated by comprehensive spectroscopic analysis with the absolute stereochemistry determined by the CD approach coupled with theoretical ECD spectra computer‐generated through the Gaussian 03 program. The distinct structure and biological profile of 3 recommended it as a starting molecule for the relevant drug discovery. |
| Keywords: | Hopea chinensis immunosuppressants natural products resveratrol aneuploids structure elucidation |