“On‐Water,” Microwave‐Assisted,Pd‐Catalyzed Synthesis of Indoles from Imines and o‐Difunctionalized Arenes |
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Authors: | Prof José Barluenga Dr Agustín Jiménez‐Aquino Prof Fernando Aznar Dr Carlos Valdés |
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Institution: | Instituto Universitario de Química Organometálica “Enrique Moles”, Universidad de Oviedo, c/Julián Clavería 8. Oviedo 33006 (Spain), Fax: (+34)?985103450 |
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Abstract: | Regioselectively substituted indoles are prepared by a Pd‐catalyzed C? C/C? N bond‐forming sequence from imines and o‐dihaloarenes or o‐haloarene sulfonates. The heterogeneous reaction as a suspension in water and under microwave heating offers important advantages in comparison with the conventional reaction in an organic solvent, among them, operational simplicity, the employment of KOH solutions instead of alkoxides, and a dramatic reduction of reaction times. |
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Keywords: | heterogeneous catalysis indoles microwave chemistry palladium water chemistry |
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