Highly Efficient Palladacycle/Dihydroimidazolium Chloride System for the Suzuki‐Miyaura Cross‐Coupling of Aryl Halides (I,Br, Cl) with Arylboronic Acids |
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| Authors: | Haiming Wang Jinping Wang Wenwei Qiu Dr Fan Yang Xiaofeng Liu Jie Tang |
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| Institution: | 1. Institute of Medicinal Chemistry, Department of Chemistry, East China Normal University, Shanghai 200062, China;2. Reata Pharmaceuticals, Inc. 2801 Gateway Drive Suite 150, Irving, Texas 75063, USA |
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| Abstract: | A combination of a tertiary amine‐based palladacycle and an N‐heterocyclic carbene ligand precursor ( 1 , N,N‐bis‐mesityl‐4,5‐dihydroimidazolium chloride) has been applied to catalyze the Suzuki‐Miyaura cross‐coupling of aryl halides with arylboronic acids. The substrate scope is general: a variety of electron rich and deficient aryl halides (I, Br, Cl) and arylboronic acids were found to undergo the cross‐coupling reaction in good to excellent yields at low catalyst loading of 0.01–1 mol%. |
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| Keywords: | Suzuki‐Miyaura reaction N‐heterocyclic carbine palladacycle aryl halides |
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