An efficient and green approach: One pot,multi component,reusable catalyzed synthesis of pyranopyrazoles and investigation of biological assays |
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| Authors: | Guda Mallikarjuna Reddy Jarem Raul Garcia Vemulapati Hanuman Reddy Avula Krishna Kumari Grigory V Zyryanov Gutha Yuvaraja |
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| Institution: | 1. Ural Federal University, Chemical Engineering Institute, Yekaterinburg 620002, Russian Federation;2. Department of Chemistry, State University of Ponta Grossa, Ponta Grossa, Parana State, Brazil;3. Natural Product Chemistry, Indian Institute of Chemical Technology, Tarnaka, 500 007 Hyderabad, India;4. Biology Division, Indian Institute of Chemical Technology, Hyderabad 500 007, TS, India;5. Ural Division of the Russian Academy of Sciences, I. Ya. Postovskiy Institute of Organic Synthesis, 22 S. Kovalevskoy Street, Yekaterinburg, Russian Federation;6. School of Environmental Science and Engineering, Guangdong Provincial Key Laboratory for Radionuclides Pollution Control and Resources, Guangzhou University, Guangzhou 510006, China |
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| Abstract: | An ecofriendly itinerary for the synthesis of pyranopyrazole derivatives having thioether link has been established via reusable, green catalyst, green solvent and multicomponent domino approach. To avoid impurities, usage of toxic solvents, toxic catalyst, simple workup and quantitative yields were strategies of this method. In addition, all the reported compounds were tested for their antioxidant and antibacterial properties. Some compounds displayed higher antioxidant activity than the standard drug (6a and 6j), while some other active compounds showed prominent antibacterial activity (6e and 6n). The results demonstrated that these active compounds may be used to support as a decent stand for further investigation in a way to ascertain innovative antioxidant and antibacterial medicines. |
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| Keywords: | Green synthesis Ecofriendly solvent Pyranopyrazoles Antioxidant Antibacterial |
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