Phytoquinoids and Secoprezizaane‐Type Sesquiterpenes from Illicium arborescens |
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| Authors: | Jiun‐Yang Chang Mohamed?H Abd?El‐Razek Yu‐Hui Chen Yuan‐Bin Cheng Shun‐Ying Chen Ching‐Te Chien Yao‐Haur Kuo Ya‐Ching Shen |
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| Institution: | 1. Department of Marine Biotechnology and Resources, National Sun Yat‐Sen University, Kaohsiung 804, Taiwan, R.O.C.;2. School of Pharmacy, College of Medicine, National Taiwan University, Jen‐Ai Rd. Sec.?1, Taipei 100, Taiwan, R.O.C. (phone: 886‐2‐23123456 ext 62226;3. fax: 886‐02‐2391‐9098);4. Division of Silviculture, Taiwan Forestry Research Institute, Taipei, Taiwan, R.O.C.;5. National Research Institute of Chinese Medicine, Taipei, Taiwan, R.O.C. |
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| Abstract: | A phytochemical investigation of the MeOH extract of Illicium arborescens yielded the two new phytoquinoid epimers, 2,3‐didehydro‐5‐O‐methyl‐11‐epiillifunone E ( 1 ) and 2,3‐didehydro‐5‐O‐methylillifunone E ( 2 ), as well as five new sesquiterpene lactones (8,9‐secoprezizaane‐type sesquiterpenes). Two of them, i.e., 3 and 4 , were minwanensin‐type sesquiterpenes, the other two, i.e., 5 and 6 , had the anisatin‐type (or floridanolide type) skeleton, and the fifth, i.e., 7 , was a dunnianin‐type sesquiterpene. Their structures were established by analyses of 1D‐ and 2D‐NMR, HR‐MS, and chemical evidence. The in vitro cytotoxic activity of compounds 1 – 7 was tested against four human tumor cell lines, including HeLa (cervical epitheloid), WiDr (colon), Daoy (medulloblastoma), and Hep2 (liver carcinoma) human‐tumor cells. |
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| Keywords: | Illicium arborescens Phytoquinoid epimers Sesquiterpene lactones Lactones Illifunone E derivatives Cytotoxic activity |
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