Synthesis,Crystal Structure,Spectroscopic, Electrochemical and Antimicrobial Properties of Cu(II) Complex with the Mixed Ligands of 2,9‐Dimethyl‐1,10‐phenanthroline and 4‐Hydroxypyridine‐2,6‐dicarboxylic Acid |
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| Authors: | Zohreh Derikvand Gholam Reza Talei Hossein Aghabozorg Marilyn M. Olmstead Azadeh Azadbakht Andya Nemati Jafar Attar Gharamaleki |
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| Affiliation: | 1. Department of Chemistry, Faculty of Science, Islamic Azad University, Khorramabad Branch, Khorramabad, Iran;2. Department of Microbiology, Faculty of Medicine, Lorestan University of Medical Sciences, Razi Street, Khorramabad 68198, Iran;3. Faculty of Chemistry, Tarbiat Moallem University, Tehran, Iran;4. Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616‐5292, USA;5. Iran Compiling Encyclopedia Foundation, Tajrish, Tehran, Iran;6. Young Researchers Club, Islamic Azad University, North Tehran Branch, Tehran, Iran |
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| Abstract: | A mononuclear Cu(II) complex with mixed ligands, formulated as [Cu(hypydc)(dmp)]·H2O (hypydc=4‐hydroxypyridine‐2,6‐dicarboxylate, dmp=2,9‐dimethyl‐1,10‐phenanthroline), was synthesized and well characterized by single crystal X‐ray diffraction analysis, as well as spectroscopic (IR, UV‐Vis), and electrochemical methods. The Cu(II) atom exhibits a distorted square‐pyramidal geometry. Intermolecular O? H···O and C? H···O hydrogen bonds, π‐π stacking interactions and C? H···π interactions seem to be effective in the stabilization of the crystal structure. The complex was also evaluated for its antimicrobial activity using in vitro microdilution methods. Six standard bacteria and a strain of Candida albicans were used for the antimicrobial activities. There was a very strong activity against Candida albicans and significant activities against Enterococcus fecalis, Listeria monocytogenes, Bacillus cereus and Staphylococcus aureus, indicating important biological activities of the complex. |
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| Keywords: | copper(II) complex crystal structure antimicrobial activitiy |
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