A Novel Potentiometric Detection Strategy for the Determination of Amlodipine Besylate Based on Functionalized Particles |
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| Authors: | Amira M El‐Kosasy Shereen M Tawakkol Miriam F Ayad Ahmed I Sheta |
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| Institution: | 1. Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, 11566 Cairo, Egypt;2. Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt;3. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Candaian University, Giza, Egypt |
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| Abstract: | A novel potentiometric strategy based on functionalized magnetite nanoparticles and microparticles were compared with the classical potentiometric strategy. This strategy provided nano‐ and microsized particles that were highly dispersed and coated with ionophore and plasticizer to promote an in situ cooperative ion‐pairing interaction between the ionophore and the analyte present in inner solution of sensor membrane, compared to the classical technique. Three amlodipine (AML) sensors were constructed using functionalized nanoparticles in sensor 1; microparticles in sensor 2, as ionophores, and the polymeric membrane ionophoric property in sensor 3. |
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| Keywords: | Amlodipine AML Nanoparticles Microparticles Potentiometric |
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