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Application of Non‐Stop‐Flow Differential Pulse Voltammetry at a Tubular Detector of Silver Solid Amalgam for Electrochemical Determination of Lomustine (CCNU) |
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| Authors: | Oksana Josyp?uk Ji?í Barek Bohdan Josyp?uk |
| Institution: | 1. Charles University in Prague, Faculty of Science, University research center UNCE “Supramolecular chemistry”, Department of Analytical Chemistry, UNESCO Laboratory of Environmental Electrochemistry, Albertov 6, CZ‐128 43 Prague 2, Czech Republic;2. J. Heyrovsky Institute of Physical Chemistry of AS CR, v.v.i., Department of Biophysical Chemistry, Dolejskova 3, Prague, Czech Republic |
| Abstract: | An application of the flow differential pulse voltammetry with tubular detector based on silver solid amalgam for determination of antineoplastic drug lomustine in pharmaceutical preparations is presented. The highest sensitivity was obtained in 0.10 mol dm?3 MES; 2.00 mol dm?3 NaCl; pH 6.0]:EtOH (9 : 1) with flow rate 0.50 mL min?1, and the magnitude of the modulation amplitude ?0.070 V. The calibration dependence was linear in the range 1×10?6–1 × 10?4 mol dm?3 (R2=0.999). The limit of detection was 1.5×10?7 mol dm?3. This method was successfully used for determination of lomustine in real samples of chemotherapy drug CeeNU Lomustine 40 mg. |
| Keywords: | Voltammetry Flow systems Tubular detector Silver solid amalgam Chemotherapy drug Lomustine |