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Electrochemical Oxidation of Donepezil and Its Voltammetric Determination at Gold Electrode |
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| Authors: | Aleksandar R Mladenovi? Du?an ? Mijin Sa?a ? Drmani? Vlatka E Vajs Vladislava M Jovanovi? Slobodan D Petrovi? Milka L Avramov Ivi? |
| Institution: | 1. Hemofarm AD, Beogradski put bb, 26300, Vr?ac, Serbia;2. Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11120, Belgrade, Serbia;3. ICTM – Institute of Chemistry, Faculty of Chemistry, University of Belgrade, Studentski trg 2, 11000, Belgrade, Serbia;4. ICTM – Institute of Electrochemistry, University of Belgrade, Njego?eva 12, 11000, Belgrade, Serbia |
| Abstract: | The oxidative ability of donepezil, a frequently prescribed drug for the treatment of Alzheimer’s disease is reported for the first time at a gold electrode. It was oxidized by cyclic voltammetry and determined by square wave voltammetry in phosphate buffer electrolyte. Electrochemical degradation of donepezil was carried out by long term potential cycling. The identification and characterization of the major product, isolated by preparative high performance liquid chromatography, was performed by high resolution mass spectrometry and 1D and 2D nuclear magnetic resonance spectroscopy. Donepezil hydroxy derivative was identified as the major electrochemical oxidation product from donepezil. |
| Keywords: | Cyclic voltammetry Donepezil Gold electrode Oxidation Square wave voltammetry |