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Genetic polymorphisms of 20 short tandem repeat loci from the Han population in Henan,China
Authors:Zhan‐Qi Feng  Zhi‐An Jing  Tao Li  Qian‐Nan Guo  Xian‐Ping Zhang  Qiao‐Fang Hou  Liang‐Jie Guo  Bing Kang  Hui Zhang  Bo‐Feng Zhu  Shi‐Xiu Liao
Institution:1. Department of Urology, The First People's Hospital of Zhengzhou city, Zhengzhou, P.R. China;2. Medical Genetic Institute of Henan Province, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, P.R. China;3. Armed Police Guangxi Corps Hospital, Nanning, P.R. China;4. School of Medicine, Xi'an Jiaotong University, Xi'an, P.R. China
Abstract:The aim of this study was to investigate the genetic polymorphism of 20 short tandem repeat (STR) loci including D1S1656, D2S1338, D3S1358, D5S818, D6S1043, D7S820, D8S1179, D12S391, D13S317, D16S539, D18S51, D19S433, D21S11, CSF1PO, FGA, Penta D, Penta E, TH01, TPOX, and vWA in Han population of Henan, China and to assess its value in forensic science. Genomic DNA was extracted from 274 blood samples of unrelated healthy individuals in the Henan Han population. Alleles were amplified with PowerPlex® 21 system kit and PCR products were detected with ABI3130 genetic analyzer (Applied Biosystems) and the data were analyzed with modified PowerStats v1.2. A total of 229 alleles were observed in this Han population and the allelic frequencies ranged from 0.0020 to 0.5090 in the present study. Observed genotype distributions for each locus do not show deviations from Hardy–Weinberg equilibrium expectations (p < 0.05). The combined power of discrimination, combined power of exclusion, and combined matching probability of this 20 STR loci were 0.999999999, 0.999999994603, and 4.0433 × 10?24, respectively. The 20 STR loci are highly polymorphic in the Han population of Henan, China and they may be of great value in forensic science and human population genetics.
Keywords:Han  Henan  PowerPlex®  21 system  Short tandem repeat
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