New functionalizable alkyltrichlorosilane surface modifiers for biosensor and biomedical applications |
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Authors: | Blaszykowski Christophe Sheikh Sonia Benvenuto Pasquale Thompson Michael |
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Affiliation: | Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, Canada M5S 3H6. |
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Abstract: | We report herein three unprecedented alkyltrichlorosilane surface modifiers bearing pentafluorophenyl ester (PFP), benzothiosulfonate (BTS), or novel β-propiolactone (BPL) functionalizable terminal groups. Evidence is provided that these molecules can be prepared in very high purity (as assessed by NMR) through a last synthetic step of Pt-catalyzed alkene hydrosilylation then directly employed, without further purification, for the surface modification of quartz and medical grade stainless steel. Subsequent on-surface functionalizations with amine and thiol model molecules demonstrate the potential of these molecular adlayers to be important platforms for future applications in the bioanalytical and biomedical fields. |
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