Novel physically crosslinked polyurethane-block-poly(vinyl pyrrolidone) hydrogel biomaterials |
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Authors: | Patel Alpesh Mequanint Kibret |
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Affiliation: | Department of Chemical and Biochemical Engineering, University of Western Ontario, London, ON N6A 5B9, Canada. |
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Abstract: | Successful tissue repair and regeneration relies on the design of new biomaterials that can mediate cell interaction without inflicting undesirable responses. Novel physically crosslinked polyurethane-block-poly(vinyl pyrrolidone) hydrogel biomaterials were synthesized by the macroiniferter controlled radical polymerization method. The structures of the hydrogels were studied by FT-IR and (1)H NMR. Hydrogels with EWC up to 37 wt.-% were prepared. The presence of the PVP block significantly increased the hard-segment glass transition temperature. Vascular smooth muscle cell attachment and spreading on the hydrogels indicated that these materials have a potential for use as scaffolds in tissue engineering. |
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