Conformational control of HCl co-transporter: imidazole functionalised isophthalamide vs. 2,6-dicarboxamidopyridine |
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| Authors: | Gale Philip A Garric Joachim Light Mark E McNally Beth A Smith Bradley D |
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| Institution: | School of Chemistry, University of Southampton, Southampton, UK SO17 1BJ. philip.gale@soton.ac.uk |
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| Abstract: | Replacement of the central isophthalamide core in a synthetic HCl receptor, with a 2,6-dicarboxamidopyridine, leads to a more preorganised molecular structure that exhibits higher chloride affinity and membrane transport flux. |
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