| Effect of helium-neon laser on fast excitatory postsynaptic potential of neurons in the isolated rat superior cervical ganglia |
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| 作者姓名： | 莫华 何萍 莫宁 |
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| 作者单位： | Department of Physics，Guangxi Medical University，Nanning 530021，Department of Pharmacology，Guangxi Medical University，Nanning 530021，Department of Pharmacology，Guangxi Medical University，Nanning 530021 |
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| 基金项目： | This work was supported by the Natural Science Foun- dation of Department of Education, Guangxi, P. R. China under Grant No. 200028. |
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| 摘 要： | The aim of this study is to further measure the effect of 632.8-nm helium-neon laser on fast excitatory postsynaptic potential (f-EPSP) of postganglionic neurons in isolated rat superior cervical ganglia by means of intracellular recording techniques. The neurons with f-EPSP were irradiated by different power densities (1 - 5 mW/cm2) laser. Irradiated by the 2-mW/cm2 laser, the amplitude of the f-EPSP could augment (P < 0.05, paired t test) and even cause action potential at the end of the first 1 - 2 minutes, the f-EPSP could descend and last for 3 8 minutes. But the amplitude of the f-EPSP of neurons irradiated by the 5-mW/cm2 laser could depress for the irradiating periods. The results show that: 1) the variation of the amplitude of f-EPSP caused by laser is power density-dependent and time-dependent; 2) there exist the second-order phases in the interaction of the helium-neon laser with neurons. These findings may provide certain evidence in explanation of the mechanisms of clinical helium-neon lase
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