| Reliable folding of hybrid tetrapeptides into short β-hairpins |
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| 作者姓名： | Xue-Yi Sun Yulong Zhong Yao-Hua Li Daniel P.Miller Sagar Buttan Xiang-Xiang Wu Yukun Zhang Quan Tang Hong-Wei Tan Jin Zhu Rui Liu Eva Zurek Zhong-Lin Lu Bing Gong |
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| 作者单位： | 1. College of Chemistry, Beijing Normal University;2. Department of Chemistry, University at Buffalo, The State University of New York;3. Department of Chemistry, Hofstra University;4. Academy of Chinese Medical Science, Henan University of Chinese Medicine;5. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences |
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| 基金项目： | supported by the National Natural Science Foundation of China (No. 21778012 to Z.L. Lu, 21801020 to R. Liu)； |
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| 摘 要： | Five hybrid tetrapeptides, each consisting a central dipeptide segment of α-amino acid residues flanked by two aromatic γ-amino acid residues, are found to fold into well-defined β-hairpin conformations as shown by NMR, computational study, and X-ray structures. The turn loop of this β-hairpin motif accommodates different two-residue α-amino acid sequences from the highly flexible Gly-Gly, to the more restricted D-Pro-Gly. The presence of α-amino acid side chains enhances the stabilities of the ...
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| 收稿时间： | 16 March 2021 |
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