| Regioselective 2-alkylation of indoles with α-bromo esters catalyzed by Pd/P,P=O system |
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| 作者姓名： | Wei Tiana Bowen Li Duanshuai Tian Wenjun Tang |
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| 作者单位： | 1. State Key Laboratory of Bio-Organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences;2. School of Chemistry and Material Sciences, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences |
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| 摘 要： | A palladium-catalyzed 2-alkylation of indoles with α-bromo esters is developed by employing a P,P=O ligand. The method features excellent regioselectivities, mild reaction conditions, and good functional group compatibility. The employment of the P,P=O ligand as well as 4 A molecular sieves were crucial for the success of the transformation. Mechanistic studies indicate the reaction proceed through a radical pathway.
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| 收稿时间： | 2021-05-20 |
| 本文献已被 ScienceDirect 等数据库收录！ |
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