| Synthesis of a Novel Conjugate of Bromoarene and Polyamide Containing N-Methylimidazoles |
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| 引用本文： | Dan LIU Gu YUAN. Synthesis of a Novel Conjugate of Bromoarene and Polyamide Containing N-Methylimidazoles[J]. 中国化学快报, 2005, 16(10): 1330-1332 |
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| 作者姓名： | Dan LIU Gu YUAN |
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| 作者单位： | Department of Chemical Biology, The Key Laboratory of Bioorganic Chemistry and MolecularEngineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871 |
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| 摘 要： | DNA-photocleavage agents have generated considerable attention in chemistry,biology and medicine1,2,because their DNA-cleavage activities can be easily controlled by photoirradiation.In the past decade,several DNA-cleavage agents have been successfully attached to polyamide3,4,to obtain new conjugates with higher and specific DNA-cleavage activities.Most of them contain only one photocleavage group to induce single-strand breaks,and the conjugates inducing double-strand breaks have been ra…
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| 关 键 词： | 聚酰胺 咪唑 合成方法 DNA 氯仿反应 |
| 收稿时间： | 2005-02-21 |
Synthesis of a Novel Conjugate of Bromoarene and Polyamide Containing N-Methylimidazoles |
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| Dan;LIU;Gu;YUAN. Synthesis of a Novel Conjugate of Bromoarene and Polyamide Containing N-Methylimidazoles[J]. Chinese Chemical Letters, 2005, 16(10): 1330-1332 |
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| Authors: | Dan LIU Gu YUAN |
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| Abstract: | A novel DNA cleavage conjugate of bromoarene and polyamide containing three N-methylimidazole rings was synthesized by the chloroform reaction and the DCC/HOBT coupling reaction. |
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| Keywords: | DNA cleavage bromoarene polyamide chloroform reaction. |
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