Study on the interaction of a palladium complex with DNA |
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| Authors: | E. J. Gao H. X. Yin M. C. Zhu Y. G. Sun X. F. Gu Q. Wu L. X. Ren |
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| Affiliation: | (1) Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang, 110142, China;(2) College of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110015, China |
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| Abstract: | The complex [Pd(bipy)Cl2] (1) (bipy = 2,2′-bipyridyl) has been synthesized and characterized by NMR spectroscopy, elemental analysis and X-ray diffraction method. The first step hydrolysis reaction kinetics for the complex was studied by UV-absorption spectroscopy; the speed constant (k 1) was found to be 3.0×10?4 s?1. The fluorescence spectra have been collected to investigate the interaction of complex (1) with fish sperm DNA (FS-DNA) and the results indicate that the complex (1) has an effective intercalation within DNA. The reaction of complex (1) with adenine in ethanol/water results in the compound [Pd2(bipy)2(ade)2]Cl2·3H2O (2) (ade = adenine) whose crystal structure was determined by X-ray diffraction method. The structure is orthorhombic, Pmmn, a = 12.993(4) Å, b = 14.512(5) Å, c = 9.837(3) Å, V = 1854.8(11) Å3, Z = 2 (C30H30Cl2N14O3Pd2), final R 1 = 0.0675. The palladium complex is a binuclear cation, where two ade ligands bridge two Pd(II) centers, while each Pd(II) is also chelated by one bipy ligand. |
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| Keywords: | palladium(II) complex adenine interaction mechanism kinetics crystal structure |
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