Three-dimensional cross-linked F-actin networks: relation between network architecture and mechanical behavior |
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Authors: | Huisman E M van Dillen T Onck P R Van der Giessen E |
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Affiliation: | Micromechanics of Materials, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, NL-9747 AG Groningen, The Netherlands. |
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Abstract: | Numerical simulations are reported for the response of three-dimensional cross-linked F-actin networks when subjected to large deformations. In addition to the physiological parameters such as actin and cross-linker concentration, the model explicitly accounts for filament properties and network architecture. Complementary to two-dimensional studies, we find that the strain-stiffening characteristics depend on network architecture through the local topology around cross-links. |
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