应用2D NMR技术对多烯大环内酯抗生素——鲁丝霉素进行结构解析

多烯大环内酯抗生素是抗生素中一个化学类群，由25～37个碳原子组成大内酯环，在环的一部分有共轭多烯结构，对应部位有羟基，并由苷键连接一个或多个氨基糖。这类抗生素具有对光不稳定，抗真菌谱广，静脉给药毒性高，口服毒性低的特点。本文对放线菌-1356产生的抗真菌活性成分，四烯大环内酯——鲁丝霉素进行了UV、IR、MS、1 H NMR 和13C NMR 检测，并通过DEPT 和1 H-1H COSY、HMBC、HSQC 等2D NMR 技术对其1 H NMR 和13C NMR 数据进行了详细的解析和信号归属，并纠正了国外文献对于多烯内酯类化合物13C NMR信号归属的错误，总结了此类化合物的核磁共振谱规律。为以后此类化合物的分析鉴定提供了更完善的依据。

Structure Elucidation of Polyene Macrolide Antibiotic Lucensomycin by 2D NMR

Polyene macrolide antibiotic is composed of 25 to 37 carbons with conjugated polyene fragment, substituted by hydroxyl and glycosidation of aminopolysaccharide. It has the characteristics of light unstability, wide antifungal spectrum, low toxicity by intravenous injection, high toxicity by oral administration. In this paper, it was reported that the idntification and detailed assignment of Lucensomycin, antifungal active substance produced from actinomycetes-1356, by means of UV, IR, MS, 1D and 2D NMR technology. Furthermore, the deficiency of 13C NMR data for olefinic carbons reported in literature was also corrected and the regularity for NMR data of polyene macrolide was summarized.