Function-oriented synthesis: studies aimed at the synthesis and mode of action of 1alpha-alkyldaphnane analogues |
| |
| Authors: | Wender Paul A D'Angelo Noel Elitzin Vassil I Ernst Martin Jackson-Ugueto Eileen E Kowalski John A McKendry Sharon Rehfeuter Markus Sun Robert Voigtlaender David |
| |
| Institution: | Department of Chemistry and Department of Chemical and Systems Biology, Stanford University, Stanford, California 94305-5080, USA. wenderp@stanford.edu |
| |
| Abstract: | reaction: see text] An efficient synthetic route to the ABC tricyclic core of 1alpha-alkyldaphnanes has been developed. The conformational bias imparted by the C6-C9 oxo-bridge of BC-ring system 12 was used to elaborate the ABC-ring system precursor including the introduction of the beta-C5 hydroxyl group. A completely diastereoselective palladium-catalyzed enyne cyclization was then employed to establish the A-ring with a C1 appendage. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
