Synthesis, structure and antifungal activity of new 3-[(5-aryl-1,3,4-oxadiazol-2-yl)methyl]benzo[d]thiazol-2(3H)-ones |
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Authors: | Weng Jian-Quan Liu Xing-Hai Huang Hua Tan Cheng-Xia Chen Jie |
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Institution: | College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, China. |
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Abstract: | A series of new 3-(5-aryl-1,3,4-oxadiazol-2-yl)methy])benzod]thiazol-2(3H)-ones were synthesized by reaction of (5-substituted-2-oxobenzothiazolin-3-yl)-acetohydrazide with various aromatic acids in POCl(3) under reflux conditions. The structures of the title compounds were confirmed by 1H-NMR, 13C-NMR, IR, MS and elemental analysis. Furthermore, the structure of compound 4i was determined by single-crystal X-ray diffraction. The preliminary bioassy results indicated that some of them showed moderate inhibition activity against Colletotrichum orbiculare, Botrytis cinerea and Rhizoctonia solani. |
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