Preparative LC separation and isolation of enantiomerically pure olefins |
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Authors: | J. Köhler A. Deege G. Schomburg |
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Affiliation: | (1) Max-Planck-Institut für Kohlenforschung, P.O. Box 011325, D-4330 Mülheim/Ruhr, FRG |
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Abstract: | Summary Diastereomer formation by the reaction of chiral olefins with optically active platinum complexes followed by LC separation of the diastereomers, and on-line or off-line release of the olefins from the complexes by ligand exchange yield optically pure enantiomers.The 100% dextrostetatory enantiomer of exo-2-vinylbicyclo[2.2.1]heptane (vinylnorbornane) could be isolated by an off-line method and was used for polarimetric measurements before and after preparative scale gas chromatographic clean-up.The initial valuable platinum complex could be easily recovered without loss. |
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Keywords: | Enantiomeric olefins Platinum complexes Ligand exchange Preparative gas chromatography Preparative column-liquid chromatography Column switching |
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