|
|||||
|
|
Modified asymmetric strecker reaction of aldehyde with secondary amine: a protocol for the synthesis of s-clopidogrel (an antiplatelet agent) |
|
| Authors: | Arghya Sadhukhan S Saravanan Noor-Ul H Khan Rukhsana I Kureshy Sayed H R Abdi Hari C Bajaj |
| Institution: | Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific & Industrial Research (CSIR), G. B. Marg, Bhavnagar- 364 021, Gujarat, India. |
| Abstract: | A first approach for catalytic asymmetric Strecker reaction of aldehydes with a secondary amine in the presence of sodium fluoride using hydroquinine as chiral catalyst was developed. The catalytic system gave α-aminonitriles in excellent yields (up to 95%) and high enantioselectivities (er up to 94:6). The efficacy of the chiral product was successfully fulfilled in the improved synthesis of (S)-clopidogrel (an antiplatelet agent). |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ | |