The prenylated dioxopiperazine alkaloid Cristatin A has selective telomeric DNA G-quadruplex stabilising properties |
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| Authors: | Khondaker M Rahman Mohammad D Hossain Mohammad H Sohrab Alex F Drake Tam T Bui Jarmila Husby Mekala Gunaratnam Stephen Neidle Choudhury M Hasan David E Thurston |
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| Affiliation: | Department of Pharmacy, King's College London, Stamford Street, London, SE18WA, UK. david.thurston@kcl.ac.uk. |
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| Abstract: | Cristatin A (1a/b), a prenylated dioxopiperazine alkaloid, has been shown to bind selectively to telomeric quadruplex DNA using a FRET-based DNA melting assay. Crucially, the molecule is more drug-like than most previously identified quadruplex-binding agents, and provides a unique chemical scaffold for future chemical biology and drug discovery studies. |
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