Catalytic asymmetric [4+2] annulation initiated by an aza-rauhut-currier reaction: facile entry to highly functionalized tetrahydropyridines |
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| Authors: | Zugui Shi Peiyuan Yu Teck-Peng Loh Guofu Zhong |
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| Affiliation: | College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University, 16 Xue-Lin Street, Hangzhou 310036, Zhejiang (China); Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 (Singapore). |
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| Abstract: | Under control: The first example of chiral amino phosphine catalysts for the title reaction between vinyl ketones and N-sulfonyl-1-aza-1,3-dienes has been developed. Under ambient conditions, this protocol provides straightforward access to densely functionalized, enantioenriched tetrahydropyridines with high levels of sterecontrol in good to excellent yields. |
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| Keywords: | annulation asymmetric catalysis heterocycles ketones synthetic methods |
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