| Cytoplasmic Ca2＋ Dynamics under the Interplay between the Different IP3R Gating Models and the Plasma Membrane Ca2＋ Influx |
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| 作者姓名： | 陈晓芳 李丛鑫 王鹏业 王渭池 |
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| 作者单位： | Laboratory of Soft Matter Physics, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190 |
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| 基金项目： | Supported by the National Natural Science Foundation of China under Grant Nos 10834014, 10674173 and 30770517, and the National Basic Research Program of China under Grant No 2009CB930704. |
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| 摘 要： | The cytoplasmic Ca2＋ oscillations are investigated under the effect of CRAC channels in non-excitable cells （especially in T cells）. The oscillatory Ca2＋ signals can be modulated as the amplitude-, frequency- and mixed amplitude-frequency modulation modes dependent on the different IP3R gating models. Bifurcation analyses show that Ca2＋ signals in the single positive feedback loop model is a mixed modulation mode. In contrast, Ca2＋ signals in the Mak-McBride-Foskett model demonstrates approximately the frequency modulation mode only with slight amplitude shifts.
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| 关 键 词： | 细胞质膜 胞质钙 相互作用 模型 浇注 动力学 调制方式 振幅变化 |
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