| 两种福尔马林试剂对大鼠炎性痛诱导的行为学比较 |
| |
| 引用本文： | 黄浩,丁明敏,陈雅娟. 两种福尔马林试剂对大鼠炎性痛诱导的行为学比较[J]. 福建师范大学学报(自然科学版), 2008, 24(5) |
| |
| 作者姓名： | 黄浩 丁明敏 陈雅娟 |
| |
| 作者单位： | 1. 福建师范大学生命科学学院,福建,福州,350108;福建省发育和神经生物学重点实验室,福建,福州,350108
2. 福建师范大学生命科学学院,福建,福州,350108 |
| |
| 基金项目： | 国家自然科学基金，福建省科技厅科技计划 |
| |
| 摘 要： | 建立福尔马林疼痛模型,研究不同产地或不同生产批次福尔马林试剂对大鼠炎性痛诱导的效果,并以Dubuisson评分方法进行记录比较.结果表明,国产组第二时相疼痛时间明显短于进口组,二者之间存在极显著差异(p<0.01).不同生产批次的福尔马林试剂对大鼠的炎性痛诱导效果无显著差异.建议在经济条件允许的情况下使用进口封装的福尔马林制作疼痛模型,同一产家的福尔马林试剂在12个月内可以安全使用.
|
| 关 键 词： | 福尔马林疼痛模型 持续性疼痛 疼痛反应行为 |
Comparison of Nocifensive Behaviors Evoked by Imported and Domestic-made Formalin in Rats |
| |
| HUANG Hao,DING Ming-min,CHEN Ya-juan. Comparison of Nocifensive Behaviors Evoked by Imported and Domestic-made Formalin in Rats[J]. Journal of Fujian Teachers University(Natural Science), 2008, 24(5) |
| |
| Authors: | HUANG Hao DING Ming-min CHEN Ya-juan |
| |
| Abstract: | The present study was designed to investigate the potential difference of effects evoked by imported and domestic-made formalin.Nocifensive behaviors(lifting and licking) were evaluated by Dubuisson scoring using in-house software following subcutaneous injection of formalin into the hindpaw.The results showed that group received indigenous formalin displayed significantly less time of lifting/licking in the second phase of the formalin test than group with imported formalin.However,indigenous formalin that was made in different time evoked very similar behavioral response.It suggests that either imported or domestic-made formalin should be consistently,but not alternatively,used.If domestic-made formalin is used,it would be better used within 12 months after formalin solution was made. |
| |
| Keywords: | formalin test persistent pain nocifensive behaviors |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
