Membraneless microseparation by asymmetry in curvilinear laminar flows |
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Authors: | Seo Jeonggi Lean Meng H Kole Ashutosh |
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Affiliation: | Palo Alto Research Center, Palo Alto, CA 94304, USA. jseo@parc.com |
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Abstract: | Membraneless microseparation by asymmetric inertial migration is studied in curvilinear laminar flows and evidence of the microseparation is presented. Along a curvilinear laminar flow, transverse particle migration involves competition between three shear-flow effects; the tubular pinch effect, centrifugal force, and Dean's vortex. Equilibrating control of migration allows for particle separation to different outlets. No filter-media or external force is necessary for the microseparation utilizing only shear-flow characteristics. A double-spiral design effectively controls the migration to optimize microseparation. The concentration ratio of 10 microm beads from the two different outlets was 660 times at 92 mm/s of flow velocity. This new technology has great potential for high-throughput and low cost in bio-agent and particulate separation at both macro and micro scales. |
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