| Efficient synthesis of 4（3H）-quinazolinones using a soluble polymeric support |
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| 作者姓名： | Chang Xie Hong Xia Li Ming Guo Liu Ming Wu Ding |
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| 作者单位： | Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University, Wuhan 430079, China |
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| 基金项目： | Acknowledgment We gratefully acknowledge financial support of this work by the Natural Science Foundation of Hubei Province （No. 2006ABB016）, the National Natural Science Foundation of China （No. 20772041） and Key Project of Chinese Ministry of Education （No. 107082）. |
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| 摘 要： | 4（3H）-Quinazolinones have been synthesized from poly（ethylene glycol） （PEG） supported aza-Wittig reaction. 2-Dialkylamino- 4（3H）-quinazolinones 6 were synthesized efficiently by reaction of secondary amine with PEG-supported carbodiimides 4, which were obtained from aza-Wittig reaction of PEG-supported iminophosphoranes 3 with isocyanates.
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| 关 键 词： | 4(3H)-喹唑啉 合成 聚乙二醇 Aza-Wittig反应 碳二酰亚胺 亚胺正膦 |
| 收稿时间： | 12 November 2007 |
Efficient synthesis of 4(3H)-quinazolinones using a soluble polymeric support |
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| Chang Xie Hong Xia Li Ming Guo Liu Ming Wu Ding.Efficient synthesis of 4(3H)-quinazolinones using a soluble polymeric support[J].Chinese Chemical Letters,2008,19(5):505-508. |
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| Authors: | Chang Xie Hong Xia Li Ming Guo Liu Ming Wu Ding |
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| Institution: | Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University, Wuhan 430079, China |
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| Abstract: | 4(3H)-Quinazolinones have been synthesized from poly(ethylene glycol) (PEG) supported aza-Wittig reaction. 2-Dialkylamino-4(3H)-quinazolinones 6 were synthesized efficiently by reaction of secondary amine with PEG-supported carbodiimides 4, which were obtained from aza-Wittig reaction of PEG-supported iminophosphoranes 3 with isocyanates. |
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| Keywords: | 4(3H)-Quinazolinone Poly(ethylene glycol) supported Aza-Wittig reaction Carbodiimide Iminophosphorane |
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