Reduction of Cu(II) in matrix-assisted laser desorption/ionization mass spectrometry |
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Authors: | Zhang Juan Frankevich Vladimir Knochenmuss Richard Friess Sebastian D Zenobi Renato |
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Institution: | Department of Chemistry, Swiss Federal Institute of Technology (ETH), ETH-H?nggerberg, Zurich, Switzerland. |
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Abstract: | The mechanisms of the reduction of Cu(II) in matrix-assisted laser desorption/ionization mass spectrometry (MALDI) are studied. In MALDI mass spectra, ions cationized by copper mostly contain Cu(I) even if Cu(II) salts are added to the sample. It was found that Cu(II) was reduced to Cu(I) by gas-phase charge exchange with matrix molecules, which is a thermodynamically favorable process. Under some conditions, large amounts of free electrons are present in the plume. Cu(II) can be even more efficiently reduced to Cu(I) by free electron capture in the gas phase. The matrices studied in this work are nicotinic acid, dithranol, and 2,5-dihydroxybenzoic acid. |
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