Chromatographic developments in low flow delivery for liquid chromatography-mass spectrometry |
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| Authors: | M P Balogh C C Stacey |
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| Institution: | Waters Chromatography Division, Millipore Corporation, Milford, MA 01757. |
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| Abstract: | A method has been demonstrated for producing accurate, reproducible gradients at low microliter per minute flow-rates suitable for liquid chromatographic-mass spectrometric (LC-MS) applications using capillary chromatography columns. The technique employs a low-cost, well characterized balance-column flow-splitter which can be simply added to a high-performance LC-MS solvent delivery system. Performance of the pump for LC-MS techniques at higher flow-rates is preserved. |
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