| 2-取代芳基-4-丙酸乙酯基-1,5-苯并二氮卓衍生物的高效合成 |
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| 引用本文： | 高蕾,王兰芝.2-取代芳基-4-丙酸乙酯基-1,5-苯并二氮卓衍生物的高效合成[J].化学通报,2017,80(1):64-68. |
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| 作者姓名： | 高蕾 王兰芝 |
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| 作者单位： | 河北师范大学化学与材料科学学院 石家庄 050024,河北师范大学化学与材料科学学院 |
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| 基金项目： | 国家自然科学基金项目（21276064），河北省自然科学基金（B2016205165） |
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| 摘 要： | 以取代的芳香醛和乙酰丙酸乙酯为原料,通过克诺维纳盖尔(Knoevenagel)缩合、亲核加成、环合、脱水等过程,快速高效地合成了8种未见文献报道的2-芳基-4-丙酸乙酯基-1,5-苯并二氮杂卓化合物.通过1H NMR、13C NMR、IR、MS和单晶衍射确定了其目标产物结构,对合成目标化合物的反应条件进行了较详细的研究,并提出了可能的反应机理。
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| 关 键 词： | 克诺维纳盖尔缩合 环合 2-取代芳基-4-丙酸乙酯基-1 5-苯并二氮杂卓 |
| 收稿时间： | 2016/4/14 0:00:00 |
| 修稿时间： | 2016/6/22 0:00:00 |
An Efficicent Catalytic Synthesis of Derivatives of 2- aryl-4-yl propanoate -1,5- Benzodiazepin |
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| Gaolei and wanglanzhi.An Efficicent Catalytic Synthesis of Derivatives of 2- aryl-4-yl propanoate -1,5- Benzodiazepin[J].Chemistry,2017,80(1):64-68. |
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| Authors: | Gaolei and wanglanzhi |
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| Institution: | College of Chemistry Material Science,Hebei Normal University,College of Chemistry Material Science,Hebei Normal University |
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| Abstract: | Eight novel compounds of 2-aryl-4-yl propanoate-1,5-benzodiazepin were efficiently synthesized by the Knoevenagel reaction, nucleophilic addition reaction, dehydration cyclization reaction, using substituted aromatic aldehyde and ethyl levulinate as starting material .The structures of these new compounds were determined by 1H NMR,13C NMR, IR, MS and Diffraction. The exhaustive researches on the synthetic reaction of the class of compounds were carried out and the reaction mechanism has been unequivocally established in this paper. |
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| Keywords: | Knoenenagel reaction cyclization 2-aryl-4-yl propanoate-1 5- benzodiazepin |
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